Stability indicating potentiometric method for the determination of palonosetron HCl using two different sensors.

ABSTRACT: This paper presents a novel potentiometric approach for the determination of palonosetron HCl using two sensors; ionophore-free and ionophore-doped ones. The two sensors successfully determined the cited drug in the range of 1 × 10^-5-1 × 10^-2 M with respective Nernstian slopes of 54.9 ± 0.25 and 59.3 ± 0.16 mV/decade. Incorporating calix[8]arene as an ionophore resulted in a lower detection limit (LOD = 3.1 × 10^-6 M) and enhanced selectivity when compared to the ionophore-free sensor (LOD = 7.9 × 10^-6 M). This modification was also associated with faster response for the ionophore-doped sensor (response time = 20 s) compared to the ionophore-free one (response time = 30 s). The two sensors showed a stable response over a pH range of 3.0-8.0. They

SUBMITTER: Tantawy MA 

PROVIDER: S-EPMC9334296 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature