Region-specific microRNA alterations in marmosets carrying SLC6A4 polymorphisms are associated with anxiety-like behavior.

ABSTRACT:

Background

Psychiatric diseases such as depression and anxiety are multifactorial conditions, highly prevalent in western societies. Human studies have identified a number of high-risk genetic variants for these diseases. Among them, polymorphisms in the promoter region of the serotonin transporter gene (SLC6A4) have attracted much attention. However, due to the paucity of experimental models, molecular alterations induced by these genetic variants and how they correlate to behavioral deficits have not been examined. In this regard, marmosets have emerged as a powerful model in translational neuroscience to investigate molecular underpinnings of complex behaviors.

Methods

Here, we took advantage of naturally occurring genetic polymorphisms in marmoset SLC6A4 gene that have b

SUBMITTER: Popa N 

PROVIDER: S-EPMC9334339 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature