Clinical significance of germline telomere length and associated genetic factors in patients with neuroblastoma.

ABSTRACT: Studies investigating the relationship between germline telomere length and the clinical characteristics of tumors are very limited. This study evaluated the relationship between germline telomere length and the clinical characteristics of neuroblastoma. In addition, a genome-wide association study (GWAS) was performed to investigate the genetic factors associated with germline telomere length. The germline telomere length of peripheral blood mononuclear cells from 186 patients with neuroblastoma was measured by quantitative polymerase chain reaction. The association between germline telomere length and clinical characteristics, including long-term survival, was investigated. For the GWAS, genotyping was performed with a high-density bead chip (Illumina, San Diego, CA, USA). After strict q

SUBMITTER: Bae JS 

PROVIDER: S-EPMC9334347 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature