Duration of Treatment for Pseudomonas aeruginosa Bacteremia: a Retrospective Study.

ABSTRACT:

Introduction

There is no consensus regarding optimal duration of antibiotic therapy for Pseudomonas aeruginosa bacteremia. We aimed to evaluate the impact of short antibiotic course.

Methods

We present a retrospective multicenter study including patients with P. aeruginosa bacteremia during 2009-2015. We evaluated outcomes of patients treated with short (6-10 days) versus long (11-15 days) antibiotic courses. The primary outcome was a composite of 30-day mortality or bacteremia recurrence and/or persistence. Univariate and inverse probability treatment-weighted (IPTW) adjusted multivariate analysis for the primary outcome was performed. To avoid immortal time bias, the landmark method was used.

Results

We included 657 patients; 273 received a short antibiotic course a

SUBMITTER: Babich T 

PROVIDER: S-EPMC9334465 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature