Evidence for oligodendrocyte progenitor cell heterogeneity in the adult mouse brain.

ABSTRACT: Oligodendrocyte progenitor cells (OPCs) account for approximately 5% of the adult brain and have been historically studied for their role in myelination. In the adult brain, OPCs maintain their proliferative capacity and ability to differentiate into oligodendrocytes throughout adulthood, even though relatively few mature oligodendrocytes are produced post-developmental myelination. Recent work has begun to demonstrate that OPCs likely perform multiple functions in both homeostasis and disease and can significantly impact behavioral phenotypes such as food intake and depressive symptoms. However, the exact mechanisms through which OPCs might influence brain function remain unclear. The first step in further exploration of OPC function is to profile the transcriptional repertoire and assess

SUBMITTER: Beiter RM 

PROVIDER: S-EPMC9334628 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature