Prediction of clinically significant prostate cancer with a multimodal MRI-based radiomics nomogram.

ABSTRACT:

Objective

To develop and validate a multimodal MRI-based radiomics nomogram for predicting clinically significant prostate cancer (CS-PCa).

Methods

Patients who underwent radical prostatectomy with pre-biopsy prostate MRI in three different centers were assessed retrospectively. Totally 141 and 60 cases were included in the training and test sets in cohort 1, respectively. Then, 66 and 122 cases were enrolled in cohorts 2 and 3, as external validation sets 1 and 2, respectively. Two different manual segmentation methods were established, including lesion segmentation and whole prostate segmentation on T2WI and DWI scans, respectively. Radiomics features were obtained from the different segmentation methods and selected to construct a radiomics signature. The final nomogram w

SUBMITTER: Jing G 

PROVIDER: S-EPMC9334707 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature