Metabolic signatures in human follicular fluid identify lysophosphatidylcholine as a predictor of follicular development.

ABSTRACT: In order to investigate the metabolic characteristics of human follicular fluid (FF) and to reveal potential metabolic predictors of follicular development (FD) with clinical implications, we analyzed a total of 452 samples based on a two-stage study design. In the first stage, FF samples from both large follicles (LFs) and matched-small follicles (SFs) of 26 participants were analyzed with wide-spectrum targeted metabolomics. The metabolic signatures were described by multi-omics integration technology including metabolomic data and transcriptomic data. In the second stage, the potential biomarkers of FD were verified using enzyme-linked immunoassay with FF and blood serum from an independent 200 participants. We describe the FF metabolic signatures from ovarian follicles of different dev

SUBMITTER: Yang J 

PROVIDER: S-EPMC9334733 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature