Early surfactant and non-invasive ventilation versus intubation and surfactant: a propensity score-matched national study.

ABSTRACT:

Objective

To compare outcome after less invasive surfactant administration (LISA) and primary endotracheal intubation (non-LISA) in infants born before gestational age (GA) 28 weeks.

Setting

All neonatal intensive care units (NICUs) in Norway during 2012-2018.

Methods

Defined population-based data were prospectively entered into a national registry. We compared LISA infants with all non-LISA infants and with non-LISA infants who received surfactant following intubation. We used propensity score (PS) matching to identify non-LISA infants who were similar regarding potential confounders.

Main outcome variables

Rate and duration of mechanical ventilation (MV), survival, neurological and gastrointestinal morbidity, and need of supplemental oxygen or positive pressu

SUBMITTER: Reigstad H 

PROVIDER: S-EPMC9335034 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature