Prevalence and Clustering of Congenital Heart Defects Among Boys With Hypospadias.

ABSTRACT:

Importance

Hypospadias is a common birth defect of the male urinary tract that may be isolated or may co-occur with other structural malformations, including congenital heart defects (CHDs). The risk for co-occurring CHDs among boys with hypospadias remains unknown, which limits screening and genetic testing strategies.

Objective

To characterize the risk of major CHDs among boys born with hypospadias.

Design, setting, and participants

This retrospective cohort study used data from population-based birth defect surveillance programs on all male infants born in 11 US states from January 1, 1995, to December 31, 2014. Statistical analysis was performed from September 2, 2020, to March 25, 2022.

Exposure

Hypospadias.

Main outcomes and measures

Demographic an

SUBMITTER: Richard MA 

PROVIDER: S-EPMC9335139 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature