Systemic and Ocular Anti-Inflammatory Mechanisms of Green Tea Extract on Endotoxin-Induced Ocular Inflammation.

ABSTRACT:

Introduction

Green tea extract (GTE) alleviated ocular inflammations in endotoxin-induced uveitis (EIU) rat model induced by lipopolysaccharide (LPS) but the underlying mechanism is unclear.

Objectives

To investigate the systematic and local mechanisms of the alleviation by untargeted metabolomics using liquid chromatography-tandem mass spectrometry.

Methods

Sprague-Dawley rats were divided into control group, LPS treatment group, and LPS treatment group treated with GTE two hours after LPS injection. The eyes were monitored by slip lamp and electroretinography examination after 24 hours. The plasma and retina were collected for metabolomics analysis.

Results

In LPS treated rats, the iris showed hyperemia. Plasma prostaglandins, arachidonic acids, corticosteroi

SUBMITTER: Chu KO 

PROVIDER: S-EPMC9335207 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature