A general theory for temperature dependence in biology.

ABSTRACT: At present, there is no simple, first principles-based, and general model for quantitatively describing the full range of observed biological temperature responses. Here we derive a general theory for temperature dependence in biology based on Eyring-Evans-Polanyi's theory for chemical reaction rates. Assuming only that the conformational entropy of molecules changes with temperature, we derive a theory for the temperature dependence of enzyme reaction rates which takes the form of an exponential function modified by a power law and that describes the characteristic asymmetric curved temperature response. Based on a few additional principles, our model can be used to predict the temperature response above the enzyme level, thus spanning quantum to classical scales. Our theory provides an a

SUBMITTER: Arroyo JI 

PROVIDER: S-EPMC9335213 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature