Escherichia coli RclA is a highly active hypothiocyanite reductase.

ABSTRACT: Hypothiocyanite and hypothiocyanous acid (OSCN^-/HOSCN) are pseudohypohalous acids released by the innate immune system which are capable of rapidly oxidizing sulfur-containing amino acids, causing significant protein aggregation and damage to invading bacteria. HOSCN is abundant in saliva and airway secretions and has long been considered a highly specific antimicrobial that is nearly harmless to mammalian cells. However, certain bacteria, commensal and pathogenic, are able to escape damage by HOSCN and other harmful antimicrobials during inflammation, which allows them to continue to grow and, in some cases, cause severe disease. The exact genes or mechanisms by which bacteria respond to HOSCN have not yet been elucidated. We have found, in Escherichia coli, that the fla

SUBMITTER: Meredith JD 

PROVIDER: S-EPMC9335216 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature