Association Between Myopic Refractive Error and Primary Open-Angle Glaucoma: A 2-Sample Mendelian Randomization Study.

ABSTRACT:

Importance

Refractive error (RE) is the most common form of visual impairment, and myopic RE is associated with an increased risk of primary open-angle glaucoma (POAG). Whether this association represents a causal role of RE in the etiology of POAG remains unknown.

Objective

To evaluate shared genetic influences and investigate the association of myopic RE with the risk for POAG.

Design, setting, and participants

Observational analyses were used to evaluate the association between mean spherical equivalent (MSE) RE (continuous trait) or myopia (binary trait) and POAG risk in individuals from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. To quantify genetic overlap, genome-wide genetic correlation analyses were performed using genome-wide a

SUBMITTER: Choquet H 

PROVIDER: S-EPMC9335248 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature