Development and characterization of human fetal female reproductive tract organoids to understand Mullerian duct anomalies.

ABSTRACT: Müllerian ducts are paired tubular structures that give rise to most of the female reproductive organs. Any abnormalities in the development and differentiation of these ducts lead to anatomical defects in the female reproductive tract organs categorized as Müllerian duct anomalies. Due to the limited access to fetal tissues, little is understood of human reproductive tract development and the associated anomalies. Although organoids represent a powerful model to decipher human development and disease, such organoids from fetal reproductive organs are not available. Here, we developed organoids from human fetal fallopian tubes and uteri and compared them with their adult counterparts. Our results demonstrate that human fetal reproductive tract epithelia do not express some of the typical m

SUBMITTER: Venkata VD 

PROVIDER: S-EPMC9335258 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature