Brain state limits propagation of neural signals in laminar cortical circuits.

ABSTRACT: Our perception of the environment relies on the efficient propagation of neural signals across cortical networks. During the time course of a day, neural responses fluctuate dramatically as the state of the brain changes to possibly influence how electrical signals propagate across neural circuits. Despite the importance of this issue, how patterns of spiking activity propagate within neuronal circuits in different brain states remains unknown. Here, we used multielectrode laminar arrays to reveal that brain state strongly modulates the propagation of neural activity across the layers of early visual cortex (V1). We optogenetically induced synchronized state transitions within a group of neurons and examined how far electrical signals travel during wakefulness and rest. Although optogeneti

SUBMITTER: Kharas N 

PROVIDER: S-EPMC9335274 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature