The Utility of Small Fishes for the Genetic Study of Human Age-Related Disorders.

ABSTRACT: Animal models have been used to model human diseases, and among them, small fishes have been highlighted for their usefulness in various ways, such as the low cost of maintenance, ease of genetic modification, small size for easy handling, and strength in imaging studies due to their relative transparency. Recently, the use of turquoise killifish, Nothobranchius furzeri, which is known to exhibit various aging phenotypes in a short period, has attracted attention in research on aging and age-related diseases. However, when using animal models, it is important to keep their genetic background and interspecies differences in mind for translating them into human diseases. In this article, we obtained the gene symbols of protein-coding genes of turquoise killifish, medaka, zebrafish, an

SUBMITTER: Dohi E 

PROVIDER: S-EPMC9335361 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature