A model of cholinergic suppression of hippocampal ripples through disruption of balanced excitation/inhibition.

ABSTRACT: Sharp wave-ripples (140-220 Hz) are patterns of brain activity observed in the local field potential of the hippocampus which are present during memory consolidation. As rodents switch from memory consolidation to memory encoding behaviors, cholinergic inputs to the hippocampus from neurons in the medial septum-diagonal band of Broca cause a marked reduction in ripple incidence. The mechanism for this disruption in ripple power is not fully understood. In isolated neurons, the major effect of cholinergic input on hippocampal neurons is depolarization of the membrane potential, which affects both hippocampal pyramidal neurons and inhibitory interneurons. Using an existing model of ripple-frequency oscillations that includes both pyramidal neurons and interneurons, we investigated the mechan

SUBMITTER: Melonakos ED 

PROVIDER: S-EPMC9335518 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature