The prognostic value of autophagy related genes with potential protective function in Ewing sarcoma.

ABSTRACT:

Background

Ewing sarcoma (ES) is the second most common primary malignant bone tumor mainly occurring in children, adolescents and young adults with high metastasis and mortality. Autophagy has been reported to be involved in the survival of ES, but the role remains unclear. Therefore, it's necessary to investigate the prognostic value of autophagy related genes using bioinformatics methods.

Results

ATG2B, ATG10 and DAPK1 were final screened genes for a prognostic model. KM and risk score plots showed patients in high score group had better prognoses both in training and validation sets. C-indexes of the model for training and validation sets were 0.68 and 0.71, respectively. Calibration analyses indicated the model had high prediction accuracy in training and validation set

SUBMITTER: Wen J 

PROVIDER: S-EPMC9335970 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature