Evidence underscoring immunological and clinical pathological changes associated with Sarcoptes scabiei infection: synthesis and meta-analysis.

ABSTRACT:

Background

Sarcoptes scabiei is one of the most impactful mammalian parasites. There has been much research on immunological and clinical pathological changes associated with S. scabiei parasitism across a range of host species. This rich body of literature is complex, and we seek to bring that complexity together in this study. We first (1) synthesise narrative reviews of immunopathological relationships to S. scabiei infection to construct overarching hypotheses; then (2) undertake a systematic meta-analysis of primary literature on immunological and clinical pathological changes; and lastly (3) contrast our findings from the meta-analysis to our synthesis from narrative reviews.

Methods

We synthesised 55 narrative reviews into two overarching hypotheses representing type

SUBMITTER: Næsborg-Nielsen C 

PROVIDER: S-EPMC9335973 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature