Pharmacological evaluation of newly synthesized organotin IV complex for antiulcer potential.

ABSTRACT: The present study aims to investigate the newly synthesized organotin (IV) complex (2E, 2'E) dibutylstannanediyl bis (4-(4-nitrophenyl) amino)-4-oxobut-2-enoate (DTN) for its anti-ulcer potential. Characterization performed by carbon nuclear magnetic resonance spectroscopy proved that all values are in the expected ranges of the new compound. Gastroprotective activity of DTN was evaluated through in-silico, anti-H. pylori, in-vitro, in-vivo, and ex-vivo proteomic analysis. In-silico analysis shows that DTN possess stable binding with protein targets involved in gastric ulcer pathophysiology. DTN exhibited an inhibitory effect against 2,2-diphenyl-1-picrylhydrazyl, H. pylori and hydrogen potassium ATPase (H⁺/K⁺-ATPase). The antiulcer activity was performed using an eth

SUBMITTER: Azmatullah S 

PROVIDER: S-EPMC9335977 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature