A fat body transcriptome analysis of the immune responses of Rhodnius prolixus to artificial infections with bacteria.

ABSTRACT:

Background

Rhodnius prolixus is an important vector of Trypanosoma cruzi, the causal agent of Chagas disease in humans. Despite the medical importance of this and other triatomine vectors, the study of their immune responses has been limited to a few molecular pathways and processes. Insect immunity studies were first described for holometabolous insects such as Drosophila melanogaster, and it was assumed that their immune responses were conserved in all insects. However, study of the immune responses of triatomines and other hemimetabolous insects has revealed discrepancies between these and the Drosophila model.

Methods

To expand our understanding of innate immune responses of triatomines to pathogens, we injected fifth instar nymphs of R. prolixus with the Gram-negative (

SUBMITTER: Salcedo-Porras N 

PROVIDER: S-EPMC9335980 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature