Drug repurposing: a systematic review on root causes, barriers and facilitators.

ABSTRACT:

Background

Repurposing is a drug development strategy receiving heightened attention after the Food and Drug Administration granted emergency use authorization of several repurposed drugs to treat Covid-19. There remain knowledge gaps on the root causes, facilitators and barriers for repurposing.

Method

This systematic review used controlled vocabulary and free text terms to search ABI/Informa, Academic Search Premier, Business Source Complete, Cochrane Library, EconLit, Google Scholar, Ovid Embase, Ovid Medline, Pubmed, Scopus, and Web of Science Core Collection databases for the characteristics, reasons and example of companies deprioritizing development of promising drugs and barriers, facilitators and examples of successful re-purposing.

Results

We identified 11,8

SUBMITTER: Krishnamurthy N 

PROVIDER: S-EPMC9336118 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature