Causal Structural Covariance Network Suggesting Structural Alterations Progression in Type 2 Diabetes Patients.

ABSTRACT:

Background and purpose

According to reports, type 2 diabetes (T2D) is a progressive disease. However, no known research has examined the progressive brain structural changes associated with T2D. The purpose of this study was to determine whether T2D patients exhibit progressive brain structural alterations and, if so, how the alterations progress.

Materials and methods

Structural magnetic resonance imaging scans were collected for 81 T2D patients and 48 sex-and age-matched healthy controls (HCs). Voxel-based morphometry (VBM) and causal structural covariance network (CaSCN) analyses were applied to investigate gray matter volume (GMV) alterations and the likely chronological processes underlying them in T2D. Two sample t-tests were performed to compare group differenc

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9336220 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature