Dynamic transcriptional atlas of male germ cells during porcine puberty.
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ABSTRACT:
SUBMITTER: Zhang LK
PROVIDER: S-EPMC9336443 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Publications
Dynamic transcriptional atlas of male germ cells during porcine puberty.
Zhang Ling-Kai LK Ma Hai-Dong HD Guo Ming M Wang Ling L Zheng Yi Y Wu Xiao-Dong XD Li Tian-Jiao TJ Lu Hong-Zhao HZ Zeng Wen-Xian WX Zhang Tao T
Zoological research 20220701 4
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Project description:ObjectiveThe purpose of this study is to report development of a malignant testicular germ cell tumor (GCT) in 2 young adult males with familial male-limited precocious puberty (FMPP) because of LHCGR pathogenic variants in 2 families. Secondarily, to study the possible relation between FMPP and testicular tumors and to investigate whether FMPP might predispose to development of malignant testicular tumors in adulthood a literature review is conducted.MethodsData on 6 cases in 2 families are obtained from the available medical records. In addition, a database search is performed in Cochrane, PubMed, and Embase for studies that report on a possible link between FMPP and testicular tumors.ResultsThe characteristics of 6 males with FMPP based on activating LH receptor (LHCGR) germline pathogenic variants are described, as are details of the testicular GCTs. Furthermore, a literature review identified 4 more patients with signs of FMPP and a (precursor of) testicular GCT in adolescence or adulthood (age 15-35 years). Additionally, 12 patients with signs of precocious puberty and, simultaneously, occurrence of a Leydig cell adenoma or Leydig cell hyperplasia are reported.ConclusionThere is a strong suggestion that FMPP might increase the risk of development of testicular GCTs in early adulthood compared with the risk in the general population. Therefore, prolonged patient monitoring from mid-pubertal age onward including instruction for self-examination and periodic testicular ultrasound investigation in patients with a germline LHCGR pathogenic variant might contribute to early detection and thus early treatment of testicular GCT.
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