DNA methylation-mediated expression of zinc finger protein 615 affects embryonic development in Bombyx mori.

ABSTRACT: Cell division and differentiation after egg fertilization are critical steps in the development of embryos from single cells to multicellular individuals and are regulated by DNA methylation via its effects on gene expression. However, the mechanisms by which DNA methylation regulates these processes in insects remain unclear. Here, we studied the impacts of DNA methylation on early embryonic development in Bombyx mori. Genome methylation and transcriptome analysis of early embryos showed that DNA methylation events mainly occurred in the 5' region of protein metabolism-related genes. The transcription factor gene zinc finger protein 615 ( ZnF615) was methylated by DNA methyltransferase 1 (Dnmt1) to be up-regulated and bind to protein metabo

SUBMITTER: Xu GF 

PROVIDER: S-EPMC9336445 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature