Fuel source shift or cost reduction: Context-dependent adaptation strategies in closely related Neodon fuscus and Lasiopodomys brandtii against hypoxia.

ABSTRACT: Oxygen is essential for most life forms. Insufficient oxygen supply can disrupt homeostasis and compromise survival, and hypoxia-induced cardiovascular failure is fatal in many animals, including humans. However, certain species have adapted and evolved to cope with hypoxic environments and are therefore good models for studying the regulatory mechanisms underlying responses to hypoxia. Here, we explored the physiological and molecular responses of the cardiovascular system in two closely related hypoxia-adapted species with different life histories, namely, Qinghai voles ( Neodon fuscus) and Brandt's voles ( Lasiopodomys brandtii), under hypoxic (10% O ₂ for 48 h) and normoxic (20.9% O ₂ for 48 h) exposure. Kunming mice ( Mus musculus) were used

SUBMITTER: Li XJ 

PROVIDER: S-EPMC9336456 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature