DNA methylation as a mediator of associations between the environment and chronic diseases: A scoping review on application of mediation analysis.

ABSTRACT: DNA methylation (DNAm) is one of the most studied epigenetic modifications. DNAm has emerged as a key biological mechanism and biomarkers to test associations between environmental exposure and outcomes in epidemiological studies. Although previous studies have focused on associations between DNAm and either exposure/outcomes, it is useful to test for mediation of the association between exposure and outcome by DNAm. The purpose of this scoping review is to introduce the methodological essence of statistical mediation analysis and to examine emerging epidemiological research applying mediation analyses. We conducted this scoping review for published peer-reviewed journals on this topic using online databases (PubMed, Scopus, Cochrane, and CINAHL) ending in December 2020. We extracted a tot

SUBMITTER: Fujii R 

PROVIDER: S-EPMC9336467 | biostudies-literature | 2022 Jun-Jul

REPOSITORIES: biostudies-literature