KIR- Ligand Interactions in Hypertensive Disorders in Pregnancy.

ABSTRACT:

Hypothesis

The activity of natural killer (NK) cells is considered an important factor for the tolerance of the fetus during pregnancy. The complications of pregnancy, such as hypertensive disorders (HDP), may be therefore associated with this immune compartment.

Methods

The current study included 41 pregnant women diagnosed with HDPs (Gestational Hypertension; GH or Preeclampsia; PE) and 21 healthy women. All the patients were under continuous obstetric care during the pregnancy and labour. The number of mother-child mismatches within killer immunoglobulin-like receptors (KIRs), their ligands [MM], and missing KIR ligands [MSLs] was assessed. KIRs and their ligands were assessed with Next Generation Sequencing (NGS) and Polymerase Chain Reaction Sequence-Specific Oligonucle

SUBMITTER: Stefanska K 

PROVIDER: S-EPMC9336683 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature