Computational analysis of protein-protein interaction network of differentially expressed genes in benign prostatic hyperplasia.

ABSTRACT: Benign prostatic hyperplasia (BPH) is a commonly occurring disease in aging men. It involves cellular proliferation of stromal and glandular tissues leading to prostate enlargement. Current drug therapies show several adverse effects such as sexual dysfunctions and cardiovascular side effects. Therefore, there is a need to develop more effective medical treatment for BPH. In this regard, we aimed to identify genes which play a critical role in BPH. We have obtained the dataset of differentially expressed genes (DEGs) of BPH from NCBI GEO. DEGs were investigated in the context of their protein-protein interactions (PPI). Hub genes i.e. genes associated with BPH were scrutinized based on the topological parameters of the PPI network. These were analyzed for functional annotations, pathway en

SUBMITTER: Sachdeva R 

PROVIDER: S-EPMC9336786 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature