In silico functional and structural characterization revealed virulent proteins of Francisella tularensis strain SCHU4.

ABSTRACT: Francisella tularensis is a pathogenic, aerobic gram-negative coccobacillus bacterium. It is the causative agent of tularemia, a rare infectious disease that can attack skin, lungs, eyes, and lymph nodes. The genome of F. tularensis has been sequenced, and ~16% of the proteome is still uncharacterized. Characterizations of these proteins are essential to find new drug targets for better therapeutics. In silico characterization of proteins has become an extremely important approach to determine the functionality of proteins as experimental functional elucidation is unable to keep pace with the current growth of the sequence database. Initially, we have annotated 577 Hypothetical Proteins (HPs) of F. tularensis strain SCHU4 with seven bioinformatics tools which ch

SUBMITTER: Goel P 

PROVIDER: S-EPMC9336787 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature