The role of leptin in indirectly mediating "somatic anxiety" symptoms in major depressive disorder.

ABSTRACT:

Background

Leptin is a multifunctional hormone secreted from adipose tissue, which plays a core role in regulating energy intake and expenditure. Evidence has demonstrated that leptin receptors are located in brain areas involved in emotional processing, and major depressive disorder (MDD) is characterized by dysfunction of emotional processing. Taken together, these features suggest that leptin may play a potential role in the pathophysiology of MDD. However, the precise roles of leptin in modulating depressive symptoms in MDD remain unclear.

Methods

Participants [18 drug-naïve MDD patients, 15 unaffected first-degree relatives of MDD patients (FDR-MDD), and 40 healthy controls] completed clinical assessments and provided blood samples for measurement of leptin levels. We e

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC9337242 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature