Functional mutations of SARS-CoV-2: implications to viral transmission, pathogenicity and immune escape.

ABSTRACT:

Abstract

The pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to major public health challenges globally. The increasing viral lineages identified indicate that the SARS-CoV-2 genome is evolving at a rapid rate. Viral genomic mutations may cause antigenic drift or shift, which are important ways by which SARS-CoV-2 escapes the human immune system and changes its transmissibility and virulence. Herein, we summarize the functional mutations in SARS-CoV-2 genomes to characterize its adaptive evolution to inform the development of vaccination, treatment as well as control and intervention measures.

SUBMITTER: Dang S 

PROVIDER: S-EPMC9337262 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature