The causal relationship between allergic diseases and heart failure: Evidence from Mendelian randomization study.

ABSTRACT:

Background

Emerging evidence shows allergic diseases, such as atopic dermatitis and asthma, are risk factors of heart failure. However, the causal relationship between allergic diseases and heart failure is not clear.

Methods

We performed a two-sample Mendelian randomization analysis between allergic diseases and heart failure using summary statistics of genome-wide association studies from large GWAS consortia, with total sample size of 1.2 million. Independent instrumental variables for asthma and atopic dermatitis (P<1×10-5) were used as the exposure. We applied five models for the Mendelian randomization analysis. Finally, we performed the sensitivity analyses to assess the robustness of the results.

Results

We have identified 55 independent single nucleotide poly

SUBMITTER: Guo YG 

PROVIDER: S-EPMC9337678 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature