Antimicrobial agents for the treatment of enteric fever chronic carriage: A systematic review.

ABSTRACT:

Background

Chronic carriage of S. Typhi or S. Paratyphi is an important source of enteric fever transmission. Existing guidance and treatment options for this condition are limited. This systematic review aims to assess the evidence concerning the efficacy of different antimicrobials in treating enteric fever chronic carriage.

Methods

We searched major bibliographic databases using relevant keywords between 1946 and September 2021. We included all interventional studies that included patients with confirmed enteric fever chronic carriage and deployed an antimicrobial that remains in clinical practice today. Case reports and case series of under 10 patients were excluded. Two reviewers screened abstracts, selected articles for final inclusion and quality-assessed the included

SUBMITTER: McCann N 

PROVIDER: S-EPMC9337697 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature