A biomineral-inspired approach of synthesizing colloidal persistent phosphors as a multicolor, intravital light source.

ABSTRACT: Many in vivo biological techniques, such as fluorescence imaging, photodynamic therapy, and optogenetics, require light delivery into biological tissues. The limited tissue penetration of visible light discourages the use of external light sources and calls for the development of light sources that can be delivered in vivo. A promising material for internal light delivery is persistent phosphors; however, there is a scarcity of materials with strong persistent luminescence of visible light in a stable colloid to facilitate systemic delivery in vivo. Here, we used a bioinspired demineralization (BID) strategy to synthesize stable colloidal solutions of solid-state phosphors in the range of 470 to 650 nm and diameters down to 20 nm. The exceptional brightness of BID-produced colloids enables

SUBMITTER: Yang F 

PROVIDER: S-EPMC9337768 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature