Distinct brainstem to spinal cord noradrenergic pathways inversely regulate spinal neuronal activity.

ABSTRACT: Brainstem to spinal cord noradrenergic pathways include a locus coeruleus origin projection and diffuse noxious inhibitory controls. While both pathways are traditionally viewed as exerting an inhibitory effect on spinal neuronal activity, the locus coeruleus was previously shown to have a facilitatory influence on thermal nocioception according to the subpopulation of coerulean neurons activated. Coupled with knowledge of its functional modular organisation and the fact that diffuse noxious inhibitory controls are not expressed in varied animal models of chronicity, we hypothesized a regulatory role for the locus coeruleus on non-coerulean, discrete noradrenergic cell group(s). We implemented locus coeruleus targeting strategies by microinjecting canine adenovirus encoding for channelrhod

SUBMITTER: Kucharczyk MW 

PROVIDER: S-EPMC9337805 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature