Cortical phase-amplitude coupling is key to the occurrence and treatment of freezing of gait.

ABSTRACT: Freezing of gait is a debilitating symptom in advanced Parkinson's disease and responds heterogeneously to treatments such as deep brain stimulation. Recent studies indicated that cortical dysfunction is involved in the development of freezing, while evidence depicting the specific role of the primary motor cortex in the multi-circuit pathology of freezing is lacking. Since abnormal beta-gamma phase-amplitude coupling recorded from the primary motor cortex in patients with Parkinson's disease indicates parkinsonian state and responses to therapeutic deep brain stimulation, we hypothesized this metric might reveal unique information on understanding and improving therapy for freezing of gait. Here, we directly recorded potentials in the primary motor cortex using subdural electrocorticograp

SUBMITTER: Yin Z 

PROVIDER: S-EPMC9337810 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature