Na⁺ riboswitches regulate genes for diverse physiological processes in bacteria.

ABSTRACT: Organisms presumably have mechanisms to monitor and physiologically adapt to changes in cellular Na⁺ concentrations. Only a single bacterial protein has previously been demonstrated to selectively sense Na⁺ and regulate gene expression. Here we report a riboswitch class, previously called the 'DUF1646 motif', whose members selectively sense Na⁺ and regulate the expression of genes relevant to sodium biology. Many proteins encoded by Na⁺-riboswitch-regulated genes are annotated as metal ion transporters, whereas others are involved in mitigating osmotic stress or harnessing Na⁺ gradients for ATP production. Na⁺ riboswitches exhibit dissociation constants in the low mM range, and strongly reject all other alkali and alkaline e

SUBMITTER: White N 

PROVIDER: S-EPMC9337991 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature