PRMT inhibition induces a viral mimicry response in triple-negative breast cancer.
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ABSTRACT:
SUBMITTER: Wu Q
PROVIDER: S-EPMC9337992 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Publications
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer.
Wu Qin Q Wu Qin Q Nie David Y DY Ba-Alawi Wail W Ji YiShuai Y Zhang ZiWen Z Cruickshank Jennifer J Haight Jillian J Ciamponi Felipe E FE Chen Jocelyn J Duan Shili S Shen Yudao Y Liu Jing J Marhon Sajid A SA Mehdipour Parinaz P Szewczyk Magdalena M MM Dogan-Artun Nergiz N Chen WenJun W Zhang Lan Xin LX Deblois Genevieve G Prinos Panagiotis P Massirer Katlin B KB Barsyte-Lovejoy Dalia D Jin Jian J De Carvalho Daniel D DD Haibe-Kains Benjamin B Wang XiaoJia X Cescon David W DW Lupien Mathieu M Arrowsmith Cheryl H CH
Nature chemical biology 20220516 8
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the worst prognosis and few effective therapies. Here we identified MS023, an inhibitor of type I protein arginine methyltransferases (PRMTs), which has antitumor growth activity in TNBC. Pathway analysis of TNBC cell lines indicates that the activation of interferon responses before and after MS023 treatment is a functional biomarker and determinant of response, and these observations extend to a panel of hum ...[more]
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