Stochastic models of Mendelian and reverse transcriptional inheritance in state-structured cancer populations.

ABSTRACT: Recent evidence suggests that a polyaneuploid cancer cell (PACC) state may play a key role in the adaptation of cancer cells to stressful environments and in promoting therapeutic resistance. The PACC state allows cancer cells to pause cell division and to avoid DNA damage and programmed cell death. Transition to the PACC state may also lead to an increase in the cancer cell's ability to generate heritable variation (evolvability). One way this can occur is through evolutionary triage. Under this framework, cells gradually gain resistance by scaling hills on a fitness landscape through a process of mutation and selection. Another way this can happen is through self-genetic modification whereby cells in the PACC state find a viable solution to the stressor and then undergo depolyploidizatio

SUBMITTER: Bukkuri A 

PROVIDER: S-EPMC9338039 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature