Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice.

ABSTRACT: The inability of neurons to regenerate long axons within the CNS is a major impediment to improving outcome after spinal cord injury, stroke, and other CNS insults. Recent advances have uncovered an intrinsic program that involves coordinate regulation by multiple transcription factors that can be manipulated to enhance growth in the peripheral nervous system. Here, we use a systems genomics approach to characterize regulatory relationships of regeneration-associated transcription factors, identifying RE1-Silencing Transcription Factor (REST; Neuron-Restrictive Silencer Factor, NRSF) as a predicted upstream suppressor of a pro-regenerative gene program associated with axon regeneration in the CNS. We validate our predictions using multiple paradigms, showing that mature mice bearing cell t

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC9338053 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature