Nonmetastatic Castration-Resistant Prostate Cancer: Current Challenges and Trends.

ABSTRACT: Prostate carcinoma is a highly prevalent biologically and clinically diverse disease, generally associated with a consistent elevation of prostate-specific antigen levels. Castration-resistant prostate cancer represents a heterogeneous clinical setting that ranges from patients with an asymptomatic prostate-specific antigen elevation after hormone blockade failure and good performance status to patients with significant debilitating symptoms and rapidly progressive disease, leading to death. Nonmetastatic castration-resistant prostate cancer is a transient disease stage defined over specific criteria established within a sensitive time period. The majority of the patients with nonmetastatic castration-resistant prostate cancer will eventually develop metastatic lesions, associated with pro

SUBMITTER: Figueiredo A 

PROVIDER: S-EPMC9338100 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature