Impact of thymidine phosphorylase and CD163 expression on prognosis in stage II colorectal cancer.

ABSTRACT:

Background

Tumor-associated macrophages (TAM) are known to facilitate colorectal cancer (CRC) growth. High macrophage infiltration in thymidine phosphorylase (TYMP) expressing CRC may correspond to poor prognosis. The prognostic impact of the expression CD163, a receptor associated with TAM, and TYMP in stroma, respectively, tumor tissue is not yet established. The aim of this study was to identify the potential associations between TYMP and CD163 expression levels and relapse-free survival (RFS) of patients with stage II CRC, and if microdissection is of importance.

Methods

Stage II CRC patients, radically resected with relapse (n = 104), were matched to patients with a 5-year relapse-free follow-up (n = 206). Gene expression of TYMP and CD163 was analyzed in snap-frozen tu

SUBMITTER: Kaidi D 

PROVIDER: S-EPMC9338131 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature