Paternal age impairs in vitro embryo and in vivo fetal development in murine.

ABSTRACT: The association between advanced paternal age and impaired reproductive outcomes is still controversial. Several studies relate decrease in semen quality, impaired embryo/fetal development and offspring health to increased paternal age. However, some retrospective studies observed no alterations on both seminal status and reproductive outcomes in older men. Such inconsistency may be due to the influence of intrinsic and external factors, such as genetics, race, diet, social class, lifestyle and obvious ethical issues that may bias the assessment of reproductive status in humans. The use of the murine model enables prospective study and owes the establishment of homogeneous and controlled groups. This study aimed to evaluate the effect of paternal age on in vitro embryo development at 4.5 d

SUBMITTER: Stabile LA 

PROVIDER: S-EPMC9338298 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature