Evaluating white matter alterations in Parkinson's disease-related parkin S/N167 mutation carriers using tract-based spatial statistics.

ABSTRACT:

Background

Genetic susceptibility plays an important role in the pathogenesis of Parkinson's disease (PD). parkin S/N167 mutations may increase the risk of PD and affect white matter fibers in the brain. This cross-sectional study explored the effects of gene polymorphisms on white matter fiber damage in PD.

Methods

In all, 54 cases were enrolled in the study, including PD patients carrying parkin gene S/N167 mutations (G/A), PD patients without gene S/N167 mutations (G/G), and healthy controls (HC). The whole-brain white matter fiber skeleton was analyzed using the tract-based spatial statistics (TBSS) method. Two-way analysis of variance (ANOVA) and post hoc tests were used for data analyses.

Results

Two classification methods were used; one was based

SUBMITTER: Yu J 

PROVIDER: S-EPMC9338378 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature