Modulation of hepatic stellate cells by Mutaflor^® probiotic in non-alcoholic fatty liver disease management.

ABSTRACT:

Background

NAFLD and NASH are emerging as primary causes of chronic liver disease, indicating a need for an effective treatment. Mutaflor® probiotic, a microbial treatment of interest, was effective in sustaining remission in ulcerative colitis patients.

Objective

To construct a genetic-epigenetic network linked to HSC signaling as a modulator of NAFLD/NASH pathogenesis, then assess the effects of Mutaflor^® on this network.

Methods

First, in silico analysis was used to construct a genetic-epigenetic network linked to HSC signaling. Second, an investigation using rats, including HFHSD induced NASH and Mutaflor^® treated animals, was designed. Experimental procedures included biochemical and histopathologic analysis of rat blood and liver samples. A

SUBMITTER: Hany NM 

PROVIDER: S-EPMC9338485 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature