Burden of phenylketonuria in Latin American patients: a systematic review and meta-analysis of observational studies.

ABSTRACT:

Background

Phenylketonuria (PKU) is an inborn error of metabolism caused by a deficiency of the enzyme phenylalanine hydroxylase. If untreated, the complications of PKU lead to significant neucognitive and neuropsychiatric impairments, placing a burden on both the individual's quality of life and on the healthcare system. We conducted a systematic literature review to characterize the impact of PKU on affected individuals and on healthcare resources in Latin American (LATAM) countries.

Methods

Searches of the global medical literature as well as regional and local medical literature up to September 2021. Observational studies on patients with PKU from any LATAM country. Pairs of reviewers independently screened eligible articles, extracted data from included studies, and ass

SUBMITTER: Pessoa ALS 

PROVIDER: S-EPMC9338521 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature