Tendinopathy: sex bias starts from the preclinical development of tendon treatments. A systematic review.

ABSTRACT: Tendinopathies are common overuse disorders that arise both in athletes and the general population. Available tendon treatments are used both for women and men without distinction. However, the existence of a sex-based difference in tendon biology is widely demonstrated. Since basic research represents the foundation for treatment development, an equal female-male representation should be pursued in preclinical studies. This systematic review quantified the current evidence by analyzing 150 studies on 8231 animals. Preclinical studies largely neglected the importance of sex, none analyzed sex-based differences, and only 4% of the studies reported disaggregated data suitable for the analysis of treatment results in males and females. There is an alarming female under-representation, in part

SUBMITTER: Mondini Trissino da Lodi C 

PROVIDER: S-EPMC9338527 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature