Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs.

ABSTRACT:

Background

Disease resistance phenotypes are associated with immune regulatory functions and immune tolerance and have implications for both the livestock industry and human health. Microbiota plays an essential role in regulating immunity and autoimmunity in the host organism, but the influence of host-microbiota interactions on disease resistance phenotypes remains unclear. Here, multiomics analysis was performed to identify potential regulatory mechanisms of disease resistance at both the microbiome and host levels in two pig breeds.

Results

Acute colitis models were established in Min pigs and Yorkshire pigs, and control and diseased individuals were compared. Compared with Yorkshire pigs under the same nutritional and management conditions, Min pigs exhibited strong dis

SUBMITTER: Zhao X 

PROVIDER: S-EPMC9338544 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature