Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas.

ABSTRACT:

Background

Invasive lobular breast carcinoma (ILC), the second most prevalent histological subtype of breast cancer, exhibits unique molecular features compared with the more common invasive ductal carcinoma (IDC). While genomic and transcriptomic features of ILC and IDC have been characterized, genome-wide chromatin accessibility pattern differences between ILC and IDC remain largely unexplored.

Methods

Here, we characterized tumor-intrinsic chromatin accessibility differences between ILC and IDC using primary tumors from The Cancer Genome Atlas (TCGA) breast cancer assay for transposase-accessible chromatin with sequencing (ATAC-seq) dataset.

Results

We identified distinct patterns of genome-wide chromatin accessibility in ILC and IDC. Inferred patient-specific tran

SUBMITTER: Lee S 

PROVIDER: S-EPMC9338552 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature